Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Trp53tm1Att
Name:	transformation related protein 53; targeted mutation 1, Laura D Attardi
MGI ID:	MGI:3573778
Synonyms:	Trp53LSL-25,26, Trp53LSL-QS
Gene:	Trp53  Location: Chr11:69471185-69482699 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Alliance:	Trp53tm1Att page

Germline Transmission:	Earliest citation of germline transmission: J:96433
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Conditional ready, Null/knockout) Mutation:    Insertion   Mutation details: A knock in strategy was used to introduce a loxP-Stop-loxP transcriptional stop element upstream of exon 2 and p.L25Q and p.W26S substitutions into exon 2 (TTATGG>CAATCG). Northern and Western blots of mutant MEFs treated with adeno-virus cre demonstrated that transcript and protein were expressed, respectively. No expression is seen without Cre expression. (J:96433)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:	232 strains or lines available

Original:	J:96433 Johnson TM, et al., The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality. Nat Genet. 2005 Feb;37(2):145-52
All:	6 reference(s)