Summary | Transgene origin | Transgene description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(Il1rn)1Dih
Name:	transgene insertion 1, David Hirsh
MGI ID:	MGI:3573755
Synonyms:	IL-1ratg, IL1ra Tg
Transgene:	Tg(Il1rn)1Dih  Location: unknown
Alliance:	Tg(Il1rn)1Dih page

Strain of Origin:

(C57BL/6J x CBA)F2

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(Il1rn)1Dih expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Il1rn (MGI:96547)   Mutation details: This transgene contains the sequence encoding the secreted gene protein and approximately 2.0kb of upstream and 2.5kb of downstream untranslated flanking regions, and a site directed mutation (G to A) in exon 3. Northern blot analysis of liver tissue following LPS challenge detects overexpression. Two lines were created and called T14 and T16. (J:36387)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:36387 Hirsch E, et al., Functions of interleukin 1 receptor antagonist in gene knockout and overproducing mice. Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):11008-13
All:	5 reference(s)