Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Atf3tm1Dron
Name:	activating transcription factor 3; targeted mutation 1, David Ron
MGI ID:	MGI:3531501
Synonyms:	ATF3-, Atf3 KO, ATF3-KO
Gene:	Atf3  Location: Chr1:190902493-190915530 bp, - strand  Genetic Position: Chr1, 96.28 cM, cytoband H6
Alliance:	Atf3tm1Dron page

Germline Transmission:	Earliest citation of germline transmission: J:91595
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced exon "B" which contains the AUG initiation codon. Absence of protein product was confirmed by Western blot analysis.

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

List all tumor models in MMHCdb carrying Atf3tm1Dron

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Atf3 Mutation:	19 strains or lines available

Original:	J:91595 Hartman MG, et al., Role for activating transcription factor 3 in stress-induced beta-cell apoptosis. Mol Cell Biol. 2004 Jul;24(13):5721-32
All:	58 reference(s)