Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Srsf1tm1Xdfu
Name:	serine and arginine-rich splicing factor 1; targeted mutation 1, Xiang-Dong Fu
MGI ID:	MGI:3530151
Synonyms:	ASF/SF2II, Sfrs1fl
Gene:	Srsf1  Location: Chr11:87938199-87944581 bp, + strand  Genetic Position: Chr11, 52.4 cM
Alliance:	Srsf1tm1Xdfu page

Germline Transmission:	Earliest citation of germline transmission: J:96039
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 2 and a floxed neo-tk cassette was inserted downstream of exon 4. The neo-tk cassette was removed by transient expression of cre recombinase in correctly targeted ES cells. Resulting mutant animals carry loxP-flanked exons 2-4. (J:96039)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Srsf1 Mutation:	25 strains or lines available

Original:	J:96039 Xu X, et al., ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle. Cell. 2005 Jan 14;120(1):59-72
All:	13 reference(s)