Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Kmt2atm2Sjk
Name:	lysine (K)-specific methyltransferase 2A; targeted mutation 2, Stanley J Korsmeyer
MGI ID:	MGI:3528758
Synonyms:	Mll-CbbSTOP
Gene:	Kmt2a  Location: Chr9:44714652-44792594 bp, - strand  Genetic Position: Chr9, 24.84 cM
Alliance:	Kmt2atm2Sjk page

Germline Transmission:	Earliest citation of germline transmission: J:95914
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Inserted expressed sequence) Mutation:    Insertion   Mutation details: A targeting vector was designed to insert a loxP-flanked stop cassette upstream of exon 8 of the lysine (K)-specific methyltransferase 2A (Kmt2a) gene. A cassette containing 6.5-kb fragment of murine CREB binding protein (Cbp) cDNA, a Simian virus 40 polyadenylation signal (SV40 pA), and a puromycin resistance sequence (puro) was inserted into exon 8. (J:95914)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kmt2a Mutation:	135 strains or lines available

Original:	J:95914 Wang J, et al., Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease. EMBO J. 2005 Jan 26;24(2):368-81
All:	2 reference(s)