Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tmprss2tm1Psn
Name:	transmembrane protease, serine 2; targeted mutation 1, Peter Nelson
MGI ID:	MGI:3526414
Synonyms:	Tmprss2-, Tmprss2tm1Tsyk
Gene:	Tmprss2  Location: Chr16:97365882-97412395 bp, - strand  Genetic Position: Chr16, 57.53 cM, cytoband C2
Alliance:	Tmprss2tm1Psn page

Germline Transmission:	Earliest citation of germline transmission: J:105558
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was designed to replace exons 10-13 with a loxP-flanked neo. The deleted exons encode 2 of 3 catalytic residues essential for serine protease activity. Quantitative RT-PCR failed to detect transcript of exons 11 and 13. Mutants expressed only a 20% reduction in transcripts spanning exons 3 and 4 or 5 and 6, however, mutants expressed 80% less transcript of the 3' UTR than wild-type mice. Sequencing revealed that mutant transcripts alternatively splice exon 9 to exon 14. (J:105558)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

23 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tmprss2 Mutation:	46 strains or lines available

Original:	J:105558 Kim TS, et al., Phenotypic analysis of mice lacking the Tmprss2-encoded protease. Mol Cell Biol. 2006 Feb;26(3):965-75
All:	11 reference(s)