Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Plcl1tm1Mh
Name:	phospholipase C-like 1; targeted mutation 1, Masato Hirata
MGI ID:	MGI:3526123
Synonyms:	p130-, PRIP-1-, PRIP-1 KO
Gene:	Plcl1  Location: Chr1:55445080-55793444 bp, + strand  Genetic Position: Chr1, 28.15 cM
Alliance:	Plcl1tm1Mh page

Germline Transmission:	Earliest citation of germline transmission: J:92489
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A fragment of coding sequence spanning residues 82-826 of the protein was replaced with a neo. RT-PCR and immunoblot confirmed successful targeting in mutant brains. Protein activity was virtually absent in mutant brains as shown by a binding assay. (J:92489)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Plcl1 Mutation:	54 strains or lines available

Original:	J:92489 Kanematsu T, et al., Role of the PLC-related, catalytically inactive protein p130 in GABA(A) receptor function. EMBO J. 2002 Mar 1;21(5):1004-11
All:	17 reference(s)