About   Help   FAQ
Tg(TettTALuc)1Dgs
Transgene Detail
Summary
Symbol: Tg(TettTALuc)1Dgs
Name: transgene insertion 1, David G Schatz
MGI ID: MGI:3525014
Transgene: Tg(TettTALuc)1Dgs  Location: unknown  
Alliance: Tg(TettTALuc)1Dgs page
Transgene
origin
Strain of Origin:  Not Applicable
Transgene
description
Transgene Type:    Transgenic (Inducible, Reporter, Transactivator)
Inducer:    doxycycline/tetracycline
Mutation:    Insertion
 
Mutation detailsTransgenic mice were produced by co-microinjection of modified tetracycline-controlled transactivator (tTA) and luciferase genes placed under the control of tetracycline-responsive promoter elements (TREs). (J:95091)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
This line was generated from founder #17. Homozygous transgenic mice are viable and fertile. Expression of tTA in transgenic mice is both inducible and autoregulatory; expression of the transgenes are suppressed in the presence of tetracycline and highly expressed in its absence. Levels of induced transgene expression in these mice are higher than those achieved in mice carrying a transgene that utilizes a constitutive tTA system. Luciferase (in the absence of tetracycline) is expressed in spleen, thymus, lung, liver, kidney, heart, cerebrum, cerebellum, lymph nodes, and testes. High activity is found in thymus and lung; low expression is found in liver and kidney. Induction ranges from 2-fold in testes to 150-fold in thymus.
References
Original:  J:95091 Shockett P, et al., A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice. Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6522-6
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory