Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Npbwr1tm1Rck
Name:	neuropeptides B/W receptor 1; targeted mutation 1 Jeffrey M Friedman
MGI ID:	MGI:3522352
Synonyms:	Gpr7-
Gene:	Npbwr1  Location: Chr1:5983926-5987617 bp, - strand  Genetic Position: Chr1, 1.89 cM, cytoband A1
Alliance:	Npbwr1tm1Rck page

Germline Transmission:	Earliest citation of germline transmission: J:94820
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P/Ola

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: An IRES-tau-EGFP cassette was inserted into the single coding exon. Northern blot of mutant hypothalamus showed the presence of a transcript increased by 6 kb compared to wild-type, confirming the insertion of the cassette. (J:94820)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Npbwr1 Mutation:	21 strains or lines available

Original:	J:94820 Ishii M, et al., Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity. Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10540-5
All:	2 reference(s)