Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pdk4tm1Rhar
Name:	pyruvate dehydrogenase kinase, isoenzyme 4; targeted mutation 1, Robert A Harris
MGI ID:	MGI:3521806
Synonyms:	PDHK4-
Gene:	Pdk4  Location: Chr6:5483351-5496278 bp, - strand  Genetic Position: Chr6, 2.06 cM
Alliance:	Pdk4tm1Rhar page

Germline Transmission:	Earliest citation of germline transmission: J:115895
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1 and part of exon 2 were replaced with a PGK-neomycin resistance cassette. Western blot analysis confirmed the absence of translation product. (J:115895)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pdk4 Mutation:	30 strains or lines available

Original:	J:115895 Jeoung NH, et al., Role of pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) in glucose homoeostasis during starvation. Biochem J. 2006 Aug 1;397(3):417-25
All:	20 reference(s)