Ccm2Gt(RRG051)Byg
Gene trapped Allele Detail
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| Symbol: |
Ccm2Gt(RRG051)Byg |
| Name: |
cerebral cavernous malformation 2; gene trap RRG051, BayGenomics |
| MGI ID: |
MGI:3512761 |
| Synonyms: |
Ccm2Gt(pGt0Lxf)1Dmar |
| Gene: |
Ccm2 Location: Chr11:6496887-6546744 bp, + strand Genetic Position: Chr11, 4.45 cM
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| Alliance: |
Ccm2Gt(RRG051)Byg page
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Vascular malformations in the brains of Ccm2Gt(RRG051)Byg/Ccm2+ mice
Show the 1 phenotype image(s) involving this allele.
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| Mutant Cell Line: |
RRG051 |
| Germline Transmission: |
Earliest citation of germline transmission:
J:101748
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| Parent Cell Line: |
Other (see notes) (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Gene trapped (Null/knockout, Reporter) |
| Mutation: |
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Insertion of gene trap vector
Vector: pGT0Lxf
Vector Type: gene trap
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Mutation details: The pGt0Lxf gene trap vector contains a splice acceptor sequence upstream of a Beta-geo (beta-galactosidase/neomycin phosphotransferase II fusion) reporter gene; in this instance the splice acceptor was joined to a cryptic splice donor site in the vector intron, approximately 30 base pairs from the vector's 5' end, that was activated when the vector integrated into exon 6 of the gene. Transcription from the gene's endogenous promoter and splicing of the message yields a fusion mRNA joining endogenous upstream exons to the Beta-geo coding sequence. Beta-galactosidase is expressed in neurons of adult brain, strongly in caudate-putamen, olfactory tubercle, nucleus accumbens, thalamus, hippocampus and cerebellar Purkinje cells and more weakly throughout the remaining grey matter.
(J:101748, J:146527)
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| Sequence Tags: |
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Sequence tag details (1 tag)
| Tag ID |
GenBank ID |
Method |
Tag Location (trapped strand)* |
Select |
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| Genome Context: |
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Genome Browser view of this mutation
34 gene trap insertions have trapped this gene
View all gene trap sequence tags in this region
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Ccm2 Mutation: |
47 strains or lines available
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All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
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| Original: |
J:101748 Zawistowski JS, et al., CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis. Hum Mol Genet. 2005 Sep 1;14(17):2521-31 |
| All: |
8 reference(s) |
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Analysis Tools
