Pcdh12tm1Hub
Targeted Allele Detail
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| Symbol: |
Pcdh12tm1Hub |
| Name: |
protocadherin 12; targeted mutation 1, Philippe Huber |
| MGI ID: |
MGI:3512625 |
| Synonyms: |
Pcdh12- |
| Gene: |
Pcdh12 Location: Chr18:38400145-38417454 bp, - strand Genetic Position: Chr18, 20.17 cM, cytoband B3
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| Alliance: |
Pcdh12tm1Hub page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:94272
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| Parent Cell Line: |
AT1 (ES Cell)
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| Strain of Origin: |
129S2/SvPasCrl
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: 1.85 kb of the gene including the initiation codon and 1689 bp of the 5' coding sequence was replaced with a promoterless LacZ-PGK-neo. Mutant mice failed to produce LacZ expression, either due to a mislocalization of the reporter gene downstream of the promoter region or the removal of important regulatory regions after recombination. Immunoblot of protein extracts from H5V cells and placenta from mutants demonstrated a lack of product from three out of four epitope peptides.
(J:94272)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Pcdh12 Mutation: |
40 strains or lines available
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| Original: |
J:94272 Rampon C, et al., Protocadherin 12 (VE-cadherin 2) is expressed in endothelial, trophoblast, and mesangial cells. Exp Cell Res. 2005 Jan 1;302(1):48-60 |
| All: |
3 reference(s) |
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Analysis Tools
