About   Help   FAQ
Pbx3tm1Mlc
Targeted Allele Detail
Summary
Symbol: Pbx3tm1Mlc
Name: pre B cell leukemia homeobox 3; targeted mutation 1, Michael L Cleary
MGI ID: MGI:3510441
Synonyms: Pbx3-
Gene: Pbx3  Location: Chr2:34061469-34262375 bp, - strand  Genetic Position: Chr2, 22.84 cM
Alliance: Pbx3tm1Mlc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:93761
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 3 was replaced with a neomycin resistance gene in opposite transcription orientation. The deletion created an early frame-shift mutation that caused termination of the reading frame upstream of its dimerization and DNA binding domains. Western blot indicated a lack of protein in brains of mutants. (J:93761)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pbx3 Mutation:  35 strains or lines available
References
Original:  J:93761 Rhee JW, et al., Pbx3 deficiency results in central hypoventilation. Am J Pathol. 2004 Oct;165(4):1343-50
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory