Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(Pbsn-Cdc37)1Stp
Name:	transgene insertion 1, Lilia Stepanova
MGI ID:	MGI:3505712
Synonyms:	PB-CDC37.1
Transgene:	Tg(Pbsn-Cdc37)1Stp  Location: unknown
Alliance:	Tg(Pbsn-Cdc37)1Stp page

Strain of Origin:

(C57BL/6 x DBA/2)F1

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(Pbsn-Cdc37)1Stp expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Cdc37 (MGI:109531)   Mutation details: The transgene contains a rat probasin promoter, a mouse Cdc37 open reading frame, and SV40 Tag splice site/polyadenylation signal sequence. The transgenic insertion site is assumed to be on the Y chromosome as all transgenic mice are male. Transgenic mice overexpress Cdc37 in prostatic epithelia, a tissue where the endogenous Cdc37 gene product is absent or present at low levels. (J:93695)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available

Original:	J:93695 Stepanova L, et al., Induction of human Cdc37 in prostate cancer correlates with the ability of targeted Cdc37 expression to promote prostatic hyperplasia. Oncogene. 2000 Apr 27;19(18):2186-93
All:	1 reference(s)