Tg(CETP)5203Tall Transgene Detail MGI Mouse (MGI:3505595)

Tg(CETP)5203Tall
Transgene Detail

Summary

Symbol:	Tg(CETP)5203Tall
Name:	transgene insertion 5203, Alan Tall
MGI ID:	MGI:3505595
Synonyms:	CETP, NFR-CETP
Transgene:	Tg(CETP)5203Tall Location: unknown
Alliance:	Tg(CETP)5203Tall page

Transgene
origin

Strain of Origin:

(C57BL/6J x CBA/J)F1

Transgene
description

Transgene Type:

Transgenic (Humanized sequence, Inserted expressed sequence)

Mutation:

Insertion

Tg(CETP)5203Tall expresses 1 gene

Tg(CETP)5203Tall expression driven by 1 gene

Mutation details: The transgene contains the human CETP mini gene under the control of its own promoter. The mini gene consists of 3.2 Kb of 5' flanking sequence, exons 1-2 and 13-16, and 2.0 Kb of 3' flanking sequence. (J:69181)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Transgenic mice on a genetic background that involves C57BL/6J and CBA/J show a marked increase in CETP mRNA in liver when mice are fed a high fat, high cholesterol diet. Less dramatic increases are observed in spleen, small intestine and adipose tissues. Elevated plasma CETP protein levels are also observed.

References

Original:	J:69181 Jiang XC, et al., Dietary cholesterol increases transcription of the human cholesteryl ester transfer protein gene in transgenic mice. Dependence on natural flanking sequences. J Clin Invest. 1992 Oct;90(4):1290-5
All:	63 reference(s)

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