Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Del(16Cbr1-Fam3b)1Rhr
Name:	deletion, Chr 16, R H Reeves 1; deletion, chr 16, R H Reeves 1
MGI ID:	MGI:3487281
Synonyms:	Del1Rhr, Ms1Rhr
Gene:	Del(16Cbr1-Fam3b)1Rhr  Location: Chr16:93404725-97306136 bp  Genetic Position: Chr16, Syntenic

Germline Transmission:	Earliest citation of germline transmission: J:93223
Parent Cell Line:	MC1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Intergenic deletion, Intragenic deletion   Mutation details: Deletion of a 3.9 Mb segment of Chr 16 was engineered by cre-mediated recombination between single loxP sites inserted into homologous chromosomes. This deleted segment contains mouse orthologs of 33 conserved and minimally conserved genes in the human Down syndrome critical region. (J:93223)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Del(16Cbr1-Fam3b)1Rhr Mutation:	1 strain or line available

Original:	J:93223 Olson LE, et al., A chromosome 21 critical region does not cause specific down syndrome phenotypes. Science. 2004 Oct 22;306(5696):687-90
All:	7 reference(s)