Tg(KITLG)3Ygy Transgene Detail MGI Mouse (MGI:3057265)

Tg(KITLG)3Ygy
Transgene Detail

Summary

Symbol:	Tg(KITLG)3Ygy
Name:	transgene insertion 3, Yong-guang Yang
MGI ID:	MGI:3057265
Transgene:	Tg(KITLG)3Ygy Location: unknown
Alliance:	Tg(KITLG)3Ygy page

Transgene
origin

Strain of Origin:

NIH Swiss

Transgene
description

Transgene Type:

Transgenic (Inserted expressed sequence)

Mutation:

Insertion

Tg(KITLG)3Ygy expresses 1 gene

Mutation details: The transgene construct contains porcine kit ligand (KITL) controlled by the human cytomegalovirus promoter. The Tg(IL3)1Ygy, Tg(CSF2)2Ygy and Tg(KITLG)3Ygy transgenic constructs were co-injected into NIH/Swiss oocytes in David Bodine's lab at NCI. (J:94302)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available

Notes

White blood cells from mice that carry this transgene in conjunction with Tg(IL3)1Ygy and Tg(CSF2)2Ygy and that are also homozygous for Prkdc^scid are CD4^-, CD8^-, CD3^-, IgM^-, CD19^- and Mac-1⁺ by flow cytometric (FMC) analysis.

References

Original:	J:94302 Yang YG, et al., Development and analysis of transgenic mice expressing porcine hematopoietic cytokines: a model for achieving durable porcine hematopoietic chimerism across an extensive xenogeneic barrier. Xenotransplantation. 2000 Feb;7(1):58-64
All:	6 reference(s)

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