Summary | Mutation origin | Mutation description | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Trp53tm4Tyj
Name:	transformation related protein 53; targeted mutation 4, Tyler Jacks
MGI ID:	MGI:3056071
Synonyms:	S23A
Gene:	Trp53  Location: Chr11:69471185-69482699 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Alliance:	Trp53tm4Tyj page

Germline Transmission:	Earliest citation of germline transmission: J:92917
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Not Specified) Mutation:    Nucleotide substitutions   Mutation details: Serine codon 23 (TCA) in exon 2 was changed to alanine (GCA) (p.S23A). Transient cre recombinase expression excised a loxP site flanked puromycin resistance gene cassette that was inserted into intron1. RT-PCR of mutant MEFs confirmed correct targeting. The mutation prevents the phosphorylation of the residue in the encoded peptide. (J:92917)

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Trp53tm4Tyj

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:	232 strains or lines available

Original:	J:92917 MacPherson D, et al., Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23. EMBO J. 2004 Sep 15;23(18):3689-99
All:	5 reference(s)