Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: rda Name: roundabout MGI ID: MGI:3055794 Synonyms: vertigo, vto Gene: rda  Location: unknown  Genetic Position: Chr9, Syntenic Alliance: rda page

Cochlear hair cell abnormalities in rda/rda and Elmod1rda-2J/Elmod1rda-2J mice Show the 2 phenotype image(s) involving this allele.

Strain of Origin:

C57BL/6J

Allele Type:    Spontaneous (Null/knockout) Mutation:    Intergenic deletion   rda involves 2 genes/genome features (Elmod1, Tnfaip8l3) View all   Mutation details: A spontaneous deletion removed 138 kb, including exons 1-5 of Elmod1 and Tnfaip8l3. Western blot analysis confirmed the absence of protein expression in the brain. (J:187273) Inheritance:    Recessive

Molecular structure of the rda mutation

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any rda Mutation:	1 strain or line available

Original:	J:187273 Johnson KR, et al., Mutations of the mouse ELMO domain containing 1 gene (Elmod1) link small GTPase signaling to actin cytoskeleton dynamics in hair cell stereocilia. PLoS One. 2012;7(4):e36074
All:	2 reference(s)