Tg(PAI1-lacZ)1Jjb Transgene Detail MGI Mouse (MGI:3055113)

Tg(PAI1-lacZ)1Jjb
Transgene Detail

Summary

Symbol:	Tg(PAI1-lacZ)1Jjb
Name:	transgene insertion 1, Joseph J Billadello
MGI ID:	MGI:3055113
Transgene:	Tg(PAI1-lacZ)1Jjb Location: unknown
Alliance:	Tg(PAI1-lacZ)1Jjb page

Transgene
origin

Strain of Origin:

FVB/N

Transgene
description

Transgene Type:		Transgenic (Reporter)
Mutation:		Insertion
		Mutation details: The transgene contains a beta-galactosidase reporter gene driven by human plasminogen activator inhibitor type I (PAI1) promoter. (J:92928)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Transgene expression in transgenic mice is observed only in kidney from embryonic day 13 to adult, and is seen primarily in proximal tubule cells of the outer medulla. Transgene expression and activity is unchanged in response to TGFbeta and remained restricted to kidney.

References

Original:	J:92928 Emert MP, et al., The human plasminogen activator inhibitor type I gene promoter targets to kidney. Am J Physiol. 1998 Feb;274(2 Pt 2):F405-12
All:	1 reference(s)

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