Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Casp8tm1Wll
Name:	caspase 8; targeted mutation 1, David Wallach
MGI ID:	MGI:3054930
Synonyms:	Casp8F
Gene:	Casp8  Location: Chr1:58834533-58886662 bp, + strand  Genetic Position: Chr1, 29.19 cM, cytoband B
Alliance:	Casp8tm1Wll page

Germline Transmission:	Earliest citation of germline transmission: J:92722
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A targeting construct was created to place a loxP site upstream of exon 1 and a floxed neo downstream of exon 2. Transient Cre expression excised the floxed neo. (J:92722)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Casp8 Mutation:	42 strains or lines available

Original:	J:92722 Kang TB, et al., Caspase-8 serves both apoptotic and nonapoptotic roles. J Immunol. 2004 Sep 1;173(5):2976-84
All:	9 reference(s)