Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nav2Gt(OST125046)Lex
Name:	neuron navigator 2; gene trap OST125046, Lexicon Genetics
MGI ID:	MGI:3054375
Synonyms:	Nav2-, Nav2Gt1Dwem
Gene:	Nav2  Location: Chr7:48608796-49259838 bp, + strand  Genetic Position: Chr7, 31.23 cM
Alliance:	Nav2Gt(OST125046)Lex page

Mutant Cell Line:	OST125046
Germline Transmission:	Earliest citation of germline transmission: J:92175
Parent Cell Line:	Lex-1 (ES Cell)
Strain of Origin:	129S5/SvEvBrd
Project Collection:	Lexicon

Allele Type:    Gene trapped (Hypomorph) Mutation:    Insertion of gene trap vector   Mutation details: A gene trap containing a PGK-neo was inserted between exons 7 and 8. RT-PCR showed this allele to be a hypomorph, expressing the smaller isoform at comparable levels to wild-type while expression of the large isoform is abolished. (J:92175) Sequence Tags:  Sequence tag details (1 tag) Tag ID GenBank ID Method Tag Location (trapped strand)* Select OST125046 CG536757 (MGI Seq Detail) 3' RACE Chr7:49102152-49102420 bp (+) * GRCm39 (strand of gene trap mutagenesis) Selected Tags: download BLAST at NCBI Genome Context:  Genome Browser view of this mutation 33 gene trap insertions have trapped this gene View all gene trap sequence tags in this region

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	117 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nav2 Mutation:	129 strains or lines available

Original:	J:92175 Peeters PJ, et al., Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53. Brain Res Dev Brain Res. 2004 Jun 21;150(2):89-101
All:	5 reference(s)