Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Viptm1Clw
Name:	vasoactive intestinal polypeptide; targeted mutation 1, Christopher S Colwell
MGI ID:	MGI:3053090
Synonyms:	VIP-, VIP KO, VIP/PHI-
Gene:	Vip  Location: Chr10:5589218-5597617 bp, + strand  Genetic Position: Chr10, 1.97 cM, cytoband A1
Alliance:	Viptm1Clw page

Germline Transmission:	Earliest citation of germline transmission: J:86544
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin resistance gene was inserted in reverse orientation into exon 4. PCR confirmed recombination in mutant mice. Immunohistochemistry confirmed the loss of protein in homozygotes. (J:86544)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vip Mutation:	22 strains or lines available

Original:	J:86544 Colwell CS, et al., Disrupted circadian rhythms in VIP- and PHI-deficient mice. Am J Physiol Regul Integr Comp Physiol. 2003 Nov;285(5):R939-49
All:	48 reference(s)