Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mapk8ip3tm1Rjd
Name:	mitogen-activated protein kinase 8 interacting protein 3; targeted mutation 1, Roger J Davis
MGI ID:	MGI:3053053
Synonyms:	Jip3-
Gene:	Mapk8ip3  Location: Chr17:25116480-25155951 bp, - strand  Genetic Position: Chr17, 12.53 cM
Alliance:	Mapk8ip3tm1Rjd page

Germline Transmission:	Earliest citation of germline transmission: J:85160
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1 was replaced by a neomycin resistance cassette. Northern blot analysis demonstrated the loss of the transcript. This was confirmed by immunoblot analysis demonstrating the loss of the protein. (J:85160)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	50 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mapk8ip3 Mutation:	53 strains or lines available

Original:	J:85160 Kelkar N, et al., Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3). Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9843-8
All:	6 reference(s)