Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ubp1tm1Jmc
Name:	upstream binding protein 1; targeted mutation 1, John M Cunningham
MGI ID:	MGI:3052819
Synonyms:	LBP-1a-
Gene:	Ubp1  Location: Chr9:113760002-113806270 bp, + strand  Genetic Position: Chr9, 64.14 cM, cytoband F2
Alliance:	Ubp1tm1Jmc page

Germline Transmission:	Earliest citation of germline transmission: J:92266
Parent Cell Line:	AB2.1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The promoter, exon 1 and part of intron 1 were replaced with a neomycin resistance casette inserted in reverse orientation. Absence of transcription was confirmed by Northern blot analysis and RT-PCR (J:92266)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ubp1 Mutation:	33 strains or lines available

Original:	J:92266 Parekh V, et al., Defective extraembryonic angiogenesis in mice lacking LBP-1a, a member of the grainyhead family of transcription factors. Mol Cell Biol. 2004 Aug;24(16):7113-29
All:	1 reference(s)