Foxo1tm1Tf
Targeted Allele Detail
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| Symbol: |
Foxo1tm1Tf |
| Name: |
forkhead box O1; targeted mutation 1, Tatsuo Furuyama |
| MGI ID: |
MGI:3052743 |
| Synonyms: |
Foxo1- |
| Gene: |
Foxo1 Location: Chr3:52175758-52257530 bp, + strand Genetic Position: Chr3, 23.19 cM
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| Alliance: |
Foxo1tm1Tf page
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Growth retardation, abnormal development of branchial arches and pericardial swelling in Foxo1tm1Tf/Foxo1tm1Tf mice
Show the 2 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:92247
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Constitutively active) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The 5' UTR and the first 208 codons of exon 1, encoding the N-terminal half of the forkhead domain, were replaced with a targeting vector containing a floxed PGK-neo and FOXO1a cDNA, encoding a constitutively active form of the protein. RT-PCR and Western blot showed lack of wild-type transcript and protein, respectively, in mutant embryos.
(J:92247)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Foxo1 Mutation: |
31 strains or lines available
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| Original: |
J:92247 Furuyama T, et al., Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice. J Biol Chem. 2004 Aug 13;279(33):34741-9 |
| All: |
6 reference(s) |
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Analysis Tools
