Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Aadattm1Tag
Name:	aminoadipate aminotransferase; targeted mutation 1, Danilo A Tagle
MGI ID:	MGI:3052711
Synonyms:	mKat-2-
Gene:	Aadat  Location: Chr8:60958966-60998711 bp, + strand  Genetic Position: Chr8, 30.85 cM
Alliance:	Aadattm1Tag page

Germline Transmission:	Earliest citation of germline transmission: J:92240
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 2 was replaced by a PGK-neo in reverse orientation, resulting in a frameshift downstream of the targeted region. Southern blot and PCR confirmed recombination. Northern blot showed no transcript in mutants and Western blot showed no protein was translated in mutant kidneys. (J:92240)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aadat Mutation:	37 strains or lines available

Original:	J:92240 Yu P, et al., Biochemical and phenotypic abnormalities in kynurenine aminotransferase II-deficient mice. Mol Cell Biol. 2004 Aug;24(16):6919-30
All:	6 reference(s)