Tg(Ins2-TAg)1Lt Transgene Detail MGI Mouse (MGI:3052662)

Tg(Ins2-TAg)1Lt
Transgene Detail

Summary

Symbol:	Tg(Ins2-TAg)1Lt
Name:	transgene insertion 1, Edward H Leiter
MGI ID:	MGI:3052662
Synonyms:	Tg(RipTAg)1Lt
Transgene:	Tg(Ins2-TAg)1Lt Location: unknown
Alliance:	Tg(Ins2-TAg)1Lt page

Transgene
origin

Strain of Origin:

NOD/ShiLt

Transgene
description

Transgene Type:		Transgenic (Inserted expressed sequence)
Mutation:		Insertion
		Mutation details: The transgene contains rat insulin 2 promoter (Rip) and the wild-type allele of the SV40 large T antigen (TAg) gene. (J:92449)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Tumor Data

List all tumor models in MMHCdb carrying Tg(Ins2-TAg)1Lt

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available

Notes

Homozygous transgenic mice on an NOD/Lt genetic background develop pancreatic beta cell adenomas. They are able to produce 2-3 litters before the insulin secreted from the adenoma makes them too hypoglycemic.

References

Original:	J:92449 Hamaguchi K, et al., NIT-1, a pancreatic beta-cell line established from a transgenic NOD/Lt mouse. Diabetes. 1991 Jul;40(7):842-9
All:	7 reference(s)

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