Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | Notes | References

Symbol:	Slc29a1tm1Msg
Name:	solute carrier family 29 (nucleoside transporters), member 1; targeted mutation 1, Robert O Messing
MGI ID:	MGI:3052066
Synonyms:	ENT1-
Gene:	Slc29a1  Location: Chr17:45896126-45910532 bp, - strand  Genetic Position: Chr17, 22.59 cM, cytoband C
Alliance:	Slc29a1tm1Msg page

Germline Transmission:	Earliest citation of germline transmission: J:92100
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The targeting construct included exons 2-4 of the gene and a neomycin cassette flanked by loxP sequences. Clones were transfected with a Cre plasmid. ES cell lines showing a deletion of exons 2-4 and the neomycin cassette were selected for microinjection. The mutation was confirmed by PCR, Southern blot and in situ hybridization. (J:92100)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc29a1 Mutation:	40 strains or lines available

Original:	J:92100 Choi DS, et al., The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preference. Nat Neurosci. 2004 Aug;7(8):855-61
All:	24 reference(s)