Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(CAG-OVAL)916Jen
Name:	transgene insertion 916, Marc K Jenkins
MGI ID:	MGI:3050829
Synonyms:	Actin-mOVA, actin-OVA, ActmOVA, Act-mOVA, actOVA, Tg(ACTB-OVA)916Jen, Tg(CAG-OVA)916Jen
Transgene:	Tg(CAG-OVAL)916Jen  Location: unknown
Alliance:	Tg(CAG-OVAL)916Jen page

Strain of Origin:

C57BL/6

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(CAG-OVAL)916Jen expresses 1 gene Transgene expresses: Organism Expressed Gene Note chicken OVAL (396058)   Tg(CAG-OVAL)916Jen expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note chicken CAG   Mutation details: The transgene consists of a full-length chicken ovalbumin cDNA preceded by the 5' leader sequence of the mouse H2-Kb gene and followed by the DNA sequence encoding the short extracellular spacer and transmembrane domain of the mouse H2-Db gene joined to the rabbit beta-globin polyadenylation signal; its expression is driven by the chicken beta-actin promoter under control of the CMV immediate early enhancer. Ovalbumin expression was detected immunohistochemically on the surfaces of cells of all organs and shown to function in skin-graft experiments as a minor histocompatibility antigen that triggered graft rejection by a mechanism involving both CD4 and CD8 T lymphocytes. (J:91742)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:91742 Ehst BD, et al., Development of a novel transgenic mouse for the study of interactions between CD4 and CD8 T cells during graft rejection. Am J Transplant. 2003 Nov;3(11):1355-62
All:	65 reference(s)