Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ppp1r8tm1Ave
Name:	protein phosphatase 1, regulatory subunit 8; targeted mutation 1, Aleyde Van Eynde
MGI ID:	MGI:3050545
Synonyms:	NIPP1-
Gene:	Ppp1r8  Location: Chr4:132554240-132570480 bp, - strand  Genetic Position: Chr4, 65.97 cM
Alliance:	Ppp1r8tm1Ave page

Germline Transmission:	Earliest citation of germline transmission: J:91601
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 3.2 kb fragment of the promoter region and exons 1 and 2 were replaced with a neo cassette. Southern blot confirmed recombination and PCR confirmed recombination. (J:91601)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ppp1r8 Mutation:	29 strains or lines available

Original:	J:91601 Van Eynde A, et al., The nuclear scaffold protein NIPP1 is essential for early embryonic development and cell proliferation. Mol Cell Biol. 2004 Jul;24(13):5863-74
All:	6 reference(s)