Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Csktm1Tara
Name:	c-src tyrosine kinase; targeted mutation 1, Alexander Tarakovsky
MGI ID:	MGI:3050293
Synonyms:	cskfl, cskflox
Gene:	Csk  Location: Chr9:57533929-57560758 bp, - strand  Genetic Position: Chr9, 31.18 cM
Alliance:	Csktm1Tara page

Germline Transmission:	Earliest citation of germline transmission: J:49654
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted in intron 8 and a floxed HSVtk-neo selection cassette was inserted in intron 10. The selection cassette was subsequently removed from properly targeted ES cells by transient cre expression leaving exons 9 and 10 flanked by loxP sites. (J:49654)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Csk Mutation:	27 strains or lines available

Original:	J:49654 Schmedt C, et al., Csk controls antigen receptor-mediated development and selection of T-lineage cells. Nature. 1998 Aug 27;394(6696):901-4
All:	16 reference(s)