Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Slc4a2tm1Ges Name: solute carrier family 4 (anion exchanger), member 2; targeted mutation 1, Gary E Shull MGI ID: MGI:3050237 Synonyms: AE2- Gene: Slc4a2  Location: Chr5:24628939-24645945 bp, + strand  Genetic Position: Chr5, 11.74 cM Alliance: Slc4a2tm1Ges page

Growth retardation and lack of incisor tooth eruption in Slc4a2tm1Ges/Slc4a2tm1Ges mice Show the 6 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:91617
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neo cassette replaced exons 14-17. Transcripts were expected to utilize the neo polyA, thereby lacking codons 703-1237, which encode the transmembrane domains. Northern blot using probes of sequences 3' to the neo showed that wild-type mRNAs were ablated in mutants, whereas probes of sequences 5' to the neo indicated presence of transcripts consistent in size with two splice variants. An immunofluorescence assay using an antibody that recognizes the C terminus confirmed protein disruption. (J:91617)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc4a2 Mutation:	53 strains or lines available

Original:	J:91617 Gawenis LR, et al., Mice with a targeted disruption of the AE2 Cl-/HCO3- exchanger are achlorhydric. J Biol Chem. 2004 Jul 16;279(29):30531-9
All:	10 reference(s)