Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cacna1ctm1Jst
Name:	calcium channel, voltage-dependent, L type, alpha 1C subunit; targeted mutation 1, Jorg Striessnig
MGI ID:	MGI:3047071
Synonyms:	Cav1.2DHP-
Gene:	Cacna1c  Location: Chr6:118564201-119173851 bp, - strand  Genetic Position: Chr6, 55.86 cM
Alliance:	Cacna1ctm1Jst page

Germline Transmission:	Earliest citation of germline transmission: J:91092
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Not Specified) Mutations:    Insertion, Nucleotide substitutions   Mutation details: A floxed neo was inserted upstream of a mutagenized exon 24 containing T1066Y, that encodes regions of the alpha 1 subunit. Crossing with deleter mice excised the floxed neo in the germ line, leaving the mutation in exon 24. Southern blot confirmed recombination and Western blot of brain and heart membranes showed no affects of the mutation on gene expression density. (J:91092)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cacna1c Mutation:	141 strains or lines available

Original:	J:91092 Sinnegger-Brauns MJ, et al., Isoform-specific regulation of mood behavior and pancreatic beta cell and cardiovascular function by L-type Ca 2+ channels. J Clin Invest. 2004 May;113(10):1430-9
All:	10 reference(s)