Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tcf7l1tm2Efu
Name:	transcription factor 7 like 1 (T cell specific, HMG box); targeted mutation 2, Elaine Fuchs
MGI ID:	MGI:3044616
Synonyms:	Tcf3-
Gene:	Tcf7l1  Location: Chr6:72603354-72766028 bp, - strand  Genetic Position: Chr6, 32.27 cM
Alliance:	Tcf7l1tm2Efu page

Germline Transmission:	Earliest citation of germline transmission: J:90402
Parent Cell Line:	GS1 (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP flanked 64 bp segment of exon 2 and a neo cassette were inserted via homologous recombination then removed via cre mediated recombination prior to generation of chimeric mice. The resulting allele lacked exon 2 and contained a frameshift and early termination codon. Immunoblot analysis confirmed the absence of protein expression in homozygous embryos (J:90402)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	72 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcf7l1 Mutation:	84 strains or lines available

Original:	J:90402 Merrill BJ, et al., Tcf3: a transcriptional regulator of axis induction in the early embryo. Development. 2004 Jan;131(2):263-74
All:	4 reference(s)