Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(ACTB-NOTCH1)1Shn
Name:	transgene insertion 1, Jie Shen
MGI ID:	MGI:3044583
Synonyms:	CALSL-NICD
Transgene:	Tg(ACTB-NOTCH1)1Shn  Location: unknown
Alliance:	Tg(ACTB-NOTCH1)1Shn page

Strain of Origin:

C57BL/6J

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(ACTB-NOTCH1)1Shn expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human NOTCH1 (4851) Notch1  (MGI:97363)   Mutation details: This transgene consists of the chicken beta-actin promoter followed by a loxP flanked stop, the human NOTCH1 intracellular domain (amino acids 1762-2304), and an SV40 late polyadenylation signal. Cre mediated recombination removes the stop and allows expression of the NOTCH1 gene. Only single site insertions were used to generate mice. This line carries 10 - 20 copies of the transgene and protein is detectable by western blot analysis after cre mediated recombination. (J:90392)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:90392 Yang X, et al., Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev Biol. 2004 May 1;269(1):81-94
All:	7 reference(s)