Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Twsg1tm1Emdr
Name:	twisted gastrulation BMP signaling modulator 1; targeted mutation 1, E M De Robertis
MGI ID:	MGI:3044357
Synonyms:	Tsg-, Twsg1lacZ
Gene:	Twsg1  Location: Chr17:66230060-66258198 bp, - strand  Genetic Position: Chr17, 35.26 cM
Alliance:	Twsg1tm1Emdr page

Germline Transmission:	Earliest citation of germline transmission: J:90398
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: In-frame insertion of a lacZ reporter into exon 1 at the start codon resulted in the deletion of exon 1, which encodes the first 40 amino acids of the protein, including the entire signal peptide. RT-PCR indicated no transcript present in mutant embryonic cells. (J:90398)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	33 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Twsg1 Mutation:	20 strains or lines available

Original:	J:90398 Zakin L, et al., Inactivation of mouse Twisted gastrulation reveals its role in promoting Bmp4 activity during forebrain development. Development. 2004 Jan;131(2):413-24
All:	5 reference(s)