Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Admtm1Hku
Name:	adrenomedullin; targeted mutation 1, Hiroki Kurihara
MGI ID:	MGI:3043324
Synonyms:	AM-
Gene:	Adm  Location: Chr7:110226868-110229027 bp, + strand  Genetic Position: Chr7, 57.7 cM
Alliance:	Admtm1Hku page

Germline Transmission:	Earliest citation of germline transmission: J:89608
Parent Cell Line:	SM1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment encompassing all of exons 1 through 3 and a portion of exon 4 was replaced with a neo cassette inserted by homologous recombination. Transcript was undetected by RT-PCR analysis of homozygous mutant embryos. (J:89608)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

14 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adm Mutation:	13 strains or lines available

Original:	J:89608 Shindo T, et al., Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene. Circulation. 2001 Oct 16;104(16):1964-71
All:	10 reference(s)