Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Robo3tm1Matl Name: roundabout guidance receptor 3; targeted mutation 1, Marc Tessier-Lavigne MGI ID: MGI:3043150 Synonyms: Rig-1-, Robo3GFP Gene: Robo3  Location: Chr9:37327341-37344730 bp, - strand  Genetic Position: Chr9, 20.76 cM, cytoband B Alliance: Robo3tm1Matl page

Reduced internuclear commissure in Robo3tm1.1Ache/Robo3tm1.1Ache Egr2tm2(cre)Pch/Egr2+ and Robo3tm1Matl/Robo3tm1Matl mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:89438
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A portion of exon 1 including the ATG start site was replaced with a cassette containing an IRES element, a tau-GFP fusion gene, a loxP site, a PGK-1 promoter, a neomycin resitance gene, a PGK-1 polyA tail and a second loxP site. Western blot analysis confirmed the absence of protein in spinal cords from homozygous null mice. The tau-GFP fusion protein is expressed from the Robo3 promoter. (J:89438)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	40 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Robo3 Mutation:	71 strains or lines available

Original:	J:89438 Sabatier C, et al., The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons. Cell. 2004 Apr 16;117(2):157-69
All:	25 reference(s)