Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bace1tm1Bux
Name:	beta-site APP cleaving enzyme 1; targeted mutation 1, Joseph D Buxbaum
MGI ID:	MGI:3042562
Gene:	Bace1  Location: Chr9:45749878-45775694 bp, + strand  Genetic Position: Chr9, 25.22 cM
Alliance:	Bace1tm1Bux page

Germline Transmission:	Earliest citation of germline transmission: J:89370
Parent Cell Line:	Lex-1 (ES Cell)
Strain of Origin:	129S5/SvEvBrd

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: The first exon was replaced with an IRES-beta-galactosidase expression cassette and a MC1-neomycin resistance gene. Western blot analysis of brain extracts confirmed the absence of protein product. Beta-galactosidase activity driven by the Bace1 promoter was detected. (J:89370)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bace1 Mutation:	27 strains or lines available

Original:	J:89370 Pastorino L, et al., BACE (beta-secretase) modulates the processing of APLP2 in vivo. Mol Cell Neurosci. 2004 Apr;25(4):642-9
All:	2 reference(s)