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Gene Expression Data
Assay Details
Assay
Reference: J:89153 Ang SJ, et al., Spatial and temporal expression of Wnt and Dickkopf genes during murine lens development. Gene Expr Patterns. 2004 May;4(3):289-95
Assay type: RNA in situ
MGI Accession ID: MGI:3042140
Gene symbol: Dkk2
Gene name: dickkopf WNT signaling pathway inhibitor 2
Probe: Dkk2 cDNA1
Probe preparation: Antisense labelled with digoxigenin RNA
Assay notes: The majority of the data are not shown. The lens development data is summarized in Table 1. The authors state that expression of this gene during ocular development was indistinguishable as was described for Dkk3 (as shown in MGI:3042136).
Results
Specimen Table 1, Dkks: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: lens placode Weak

Specimen Table 1, Dkks: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: lens pit Present

Specimen Table 1, Dkks: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: lens epithelium Strong
TS23: lens fiber Absent

Specimen E9.5: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: future brain Weak
TS15: head mesenchyme Weak

Specimen E10.5: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: lens pit Present
TS17: optic cup Present Regionally restricted Expression is in the retinal primordia.
TS17: brain Weak
TS17: head mesenchyme Weak

Specimen E12.5: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: cornea Present
TS20: hyaloid vascular plexus Present
TS20: lens vesicle Strong Regionally restricted Expression is in the elongating primary fibers and the presumptive epithelial cells.

Specimen E14.5: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: lens epithelium Strong
TS22: lens fiber Strong Regionally restricted Expression is in the less mature elongating fibers. Expression is absent in the most mature primary fibers in the center of the lens.
TS22: cornea epithelium Strong
TS22: cornea Strong Regionally restricted Expression is in the endothelium.
TS22: cornea stroma Present
TS22: eye Present Regionally restricted Expression in the optic cup is in the margin of cells destined to form the ciliary and iridial epithelia and the developing ganglion cell layer.
TS22: hyaloid vascular plexus Weak

Specimen E18.5: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: lens epithelium Strong
TS26: lens fiber Strong Regionally restricted Expression is in the less mature elongating fibers. Expression is absent in the most mature primary fibers in the center of the lens.
TS26: cornea endothelium Strong
TS26: cornea epithelium Strong
TS26: cornea stroma Present
TS26: eye Present Regionally restricted Expression in the optic cup is in the margin of cells destined to form the ciliary and iridial epithelia, the ciliary/iridial stroma, and the developing ganglion cell layer.
TS26: hyaloid vascular plexus Weak

Specimen P2: postnatal day 2 (more )
Structure Level Pattern Image Note
TS27: cornea endothelium Strong
TS27: cornea epithelium Strong
TS27: lens epithelium Strong
TS27: lens Strong Regionally restricted Expression is in the equatorial region and is absent in cortical fiber cells.
TS27: ciliary body Present
TS27: iris Present

Specimen P8: postnatal day 8 (more )
Structure Level Pattern Image Note
TS28: cornea endothelium Strong
TS28: cornea epithelium Strong
TS28: lens epithelium Strong
TS28: lens Strong Regionally restricted Expression is in the equatorial region and is absent in cortical fiber cells.

Specimen P21: postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: lens epithelium Present Graded Expression is weaker in the central epithelium.
TS28: lens Present Regionally restricted Expression is in the equatorial region and is absent in cortical fiber cells.
TS28: cornea endothelium Strong
TS28: cornea epithelium Strong


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory