About   Help   FAQ
Zfp148tm1Kii
Targeted Allele Detail
Summary
Symbol: Zfp148tm1Kii
Name: zinc finger protein 148; targeted mutation 1, Ken-ichi Isobe
MGI ID: MGI:3040891
Gene: Zfp148  Location: Chr16:33201145-33324273 bp, + strand  Genetic Position: Chr16, 23.93 cM
Alliance: Zfp148tm1Kii page
Mutation
origin
Mouse Generated:  Earliest citation of chimera generation: J:81445
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 9, which makes up over 60% of the coding region, was replaced with a neo cassette via homologous recombination. Northern blot analysis showed decreased expression in heterozygous stem cells. (J:81445)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zfp148 Mutation:  112 strains or lines available
Notes
Haploinsufficiency of Zfp148 prevents genetic transmission of the mutated allele and generation of non-chimeric heterozygous mice. All phenotype data reported are from chimeric mice.
References
Original:  J:81445 Takeuchi A, et al., Heterozygosity with respect to Zfp148 causes complete loss of fetal germ cells during mouse embryogenesis. Nat Genet. 2003 Feb;33(2):172-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory