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Srsf2tm1Xdfu
Targeted Allele Detail
Summary
Symbol: Srsf2tm1Xdfu
Name: serine and arginine-rich splicing factor 2; targeted mutation 1, Xiang Dong Fu
MGI ID: MGI:3036846
Synonyms: SC35flox, Srsf2fl
Gene: Srsf2  Location: Chr11:116740727-116743920 bp, - strand  Genetic Position: Chr11, 81.49 cM
Alliance: Srsf2tm1Xdfu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:88668
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsLoxP sites flanking exons 1 and 2 were introduced to the gene by homologous recombination. The floxed region includes the entire coding region. The targeted allele was verified by Southern blot analysis. (J:88668)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Srsf2 Mutation:  11 strains or lines available
References
Original:  J:88668 Wang HY, et al., SC35 plays a role in T cell development and alternative splicing of CD45. Mol Cell. 2001 Feb;7(2):331-42
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory