Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lmo4tm2Sho
Name:	LIM domain only 4; targeted mutation 2, Stuart Orkin
MGI ID:	MGI:3035914
Synonyms:	Lmo4-
Gene:	Lmo4  Location: Chr3:143894291-143910981 bp, - strand  Genetic Position: Chr3, 68.61 cM
Alliance:	Lmo4tm2Sho page

Germline Transmission:	Earliest citation of germline transmission: J:88168
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: A floxed cassette containing both a PGK-neomycin gene and a cytosine deaminase gene was inserted 5' of exon 2 while a third loxP site was inserted 3' of the exon. Chimeric mice were crossed with cre expressing transgenic mice leading to the excision of both the floxed neomycin and cytosine deaminase genes as well as exon 2. Western blot analysis confirmed the absence of protein product. (J:88168)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	18 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lmo4 Mutation:	9 strains or lines available

Original:	J:88168 Hahm K, et al., Defective neural tube closure and anteroposterior patterning in mice lacking the LIM protein LMO4 or its interacting partner Deaf-1. Mol Cell Biol. 2004 Mar;24(5):2074-82
All:	4 reference(s)