Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Adam19Gt(Betageo)1Bbl
Name:	ADAM metallopeptidase domain 19; gene trap 1, Carl P Blobel
MGI ID:	MGI:3028702
Synonyms:	adam19-
Gene:	Adam19  Location: Chr11:45946819-46038170 bp, + strand  Genetic Position: Chr11, 27.54 cM, cytoband A5-B1.1
Alliance:	Adam19Gt(Betageo)1Bbl page

Germline Transmission:	Earliest citation of germline transmission: J:87592
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Gene trapped (Null/knockout, Reporter) Mutation:    Insertion of gene trap vector   Mutation details: Sequence encoding the carboxyl cysteine-rich domain was disrupted by a secretory gene trap vector containing a Beta-geo cassette. The insertion putatively interferes with proper protein folding resulting in the retention and subsequent degradation of the mutant protein in the enodplasmic reticulum. (J:87592)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

13 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adam19 Mutation:	77 strains or lines available

Original:	J:87592 Zhou HM, et al., Essential role for ADAM19 in cardiovascular morphogenesis. Mol Cell Biol. 2004 Jan;24(1):96-104
All:	3 reference(s)