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Mei1 Gene Detail
Summary
  • Symbol
    Mei1
  • Name
    meiotic double-stranded break formation protein 1
  • Synonyms
    mei1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3028590
    NCBI Gene: 74369
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr15:81954275-82011018 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 38.41 cM, cytoband E2
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    385 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3028590
 protein coding gene Chr15:81954197-82011018 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022133
 protein coding gene Chr15:82554671-82615106 (+)
A/J MGP_AJ_G0022093
 protein coding gene Chr15:79636255-79693185 (+)
AKR/J MGP_AKRJ_G0022069
 protein coding gene Chr15:81834929-81899718 (+)
BALB/cJ MGP_BALBcJ_G0022099
 protein coding gene Chr15:79681293-79744022 (+)
C3H/HeJ MGP_C3HHeJ_G0021870
 protein coding gene Chr15:81858061-81919240 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022542
 protein coding gene Chr15:85782574-85855455 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020071
 protein coding gene Chr15:76073302-76133123 (+)
CAST/EiJ MGP_CASTEiJ_G0021390
 protein coding gene Chr15:82650799-82714414 (+)
CBA/J MGP_CBAJ_G0021835
 protein coding gene Chr15:88462552-88539438 (+)
DBA/2J MGP_DBA2J_G0021963
 protein coding gene Chr15:79107358-79167110 (+)
FVB/NJ MGP_FVBNJ_G0021940
 protein coding gene Chr15:78157755-78223623 (+)
LP/J MGP_LPJ_G0022032
 protein coding gene Chr15:82700636-82763998 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021961
 protein coding gene Chr15:93386683-93454030 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022556
 protein coding gene Chr15:81944768-82010707 (+)
PWK/PhJ MGP_PWKPhJ_G0021132
 protein coding gene Chr15:79155675-79217349 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020971
 protein coding gene Chr15:81734970-81795067 (+)
WSB/EiJ MGP_WSBEiJ_G0021441
 protein coding gene Chr15:82365671-82426452 (+)



Homology
more
  • Human Ortholog
    MEI1, meiotic double-stranded break formation protein 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MEI1, meiotic double-stranded break formation protein 1
  • Synonyms
    HYDM3, SPATA38
  • Links
    NCBI Gene ID: 150365
    neXtProt AC: NX_Q5TIA1
    UniProt: Q5TIA1

  • Chr Location
    22q13.2; chr22:41699503-41799456 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MEI1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice of both sexes exhibit meiotic defects and are infertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    738
  • Tissues
    15
  • cDNA Data
    6
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74369 NCBI Gene Model | MGI Sequence Detail 56744 C57BL/6J ±  kb
    transcript NM_028897 RefSeq | MGI Sequence Detail 3991 ZRU/MplStud  
    polypeptide Q9D4I2 UniProt | EBI | MGI Sequence Detail 1268 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 6
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1890406, MGI:1921619
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 6
      Phenotypes 33
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:285676 Suzuki A, et al., Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis. Mech Dev. 2018 Apr;150:21-27
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory