Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Btlatm1Kmm
Name:	B and T lymphocyte associated; targeted mutation 1, Kenneth M Murphy
MGI ID:	MGI:3027713
Synonyms:	BTLA-
Gene:	Btla  Location: Chr16:45043121-45073258 bp, + strand  Genetic Position: Chr16, 29.52 cM
Alliance:	Btlatm1Kmm page

Germline Transmission:	Earliest citation of germline transmission: J:84084
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic region containing exons 3, 4 and 5 was replaced with a neomycin selection cassette through homologous recombination. Northern blot analysis on splenocytes derived from homozygous mice demonstrated that no detectable transcript was expressed from this allele. (J:84084)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Btla Mutation:	30 strains or lines available

Original:	J:84084 Watanabe N, et al., BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat Immunol. 2003 Jul;4(7):670-9
All:	23 reference(s)