Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gadd45btm1Flv
Name:	growth arrest and DNA-damage-inducible 45 beta; targeted mutation 1, Richard A Flavell
MGI ID:	MGI:2687355
Synonyms:	Gadd45b-
Gene:	Gadd45b  Location: Chr10:80765925-80768038 bp, + strand  Genetic Position: Chr10, 39.72 cM
Alliance:	Gadd45btm1Flv page

Germline Transmission:	Earliest citation of germline transmission: J:87396
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 3 and 4 were replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded residues 42 through 161, which make up crucial domains of the protein. (J:87396)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gadd45b Mutation:	12 strains or lines available

Original:	J:87396 Lu B, et al., Gadd45beta is important for perpetuating cognate and inflammatory signals in T cells. Nat Immunol. 2004 Jan;5(1):38-44
All:	14 reference(s)