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Ap3b1tm1Sms
Targeted Allele Detail
Summary
Symbol: Ap3b1tm1Sms
Name: adaptor-related protein complex 3, beta 1 subunit; targeted mutation 1, Suzanne L Mansour
MGI ID: MGI:2684535
Synonyms: Ap3b1LN
Gene: Ap3b1  Location: Chr13:94495468-94702825 bp, + strand  Genetic Position: Chr13, 49.22 cM
Alliance: Ap3b1tm1Sms page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66256
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn IRES-lacZ and a floxed PGKneomycin selection cassette was inserted into the coding region of the gene. Northern blot analysis on RNA derived from spleen and kidney of homozygous mice confirmed that no detectable transcript was expressed from this allele. (J:66256)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ap3b1 Mutation:  95 strains or lines available
References
Original:  J:66256 Yang W, et al., Defective organellar membrane protein trafficking in Ap3b1-deficient cells. J Cell Sci. 2000 Nov;113(Pt 22):4077-86
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory