Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Grhl3tm1Jane
Name:	grainyhead like transcription factor 3; targeted mutation 1, Stephen M Jane
MGI ID:	MGI:2684328
Synonyms:	Grhl3-
Gene:	Grhl3  Location: Chr4:135269199-135300941 bp, - strand  Genetic Position: Chr4, 67.76 cM
Alliance:	Grhl3tm1Jane page

Germline Transmission:	Earliest citation of germline transmission: J:86772
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A lacZ reporter gene replaced 2.2 kb of endogenous sequence, including exon 2 which encodes the entire transactivation domain. Northern blot and RT-PCR analysis indicated that the allele represents a null mutation. (J:86772)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	125 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grhl3 Mutation:	53 strains or lines available

Original:	J:86772 Ting SB, et al., Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3. Nat Med. 2003 Dec;9(12):1513-9
All:	13 reference(s)